rumor has been cross fire will probubly work best in ATI chipsets. But it has never been claerified or verfied which chipsets it will work in. Thught there is at lest one new intel chipset gareteed to work Best guess it will work in current Intel/Nvidia SLI & dual PCIe boards too but the info is all under wraps. Of couse the ati cards will run better on the ati chipsets. But far as thier conserned they would od course love you to by an ATI MB and ATI video card. Just as NV would like you to buy a NV MB and NV video card. So what they will run on is still unkown, offically and unoffically . As in it may work in a chipset but not be offically supported or something who knows. We are getting two far into "unkowns"