Make sure to run Driver Cleaner.NET on Windows Vista with administrator privileges. The program should ask for this, but if it does not ask for it use 1 of the following ways to run it with administrator privileges. There are 2 ways. 1. Right mouse click on the shortcut icon and select "Run as Administrator" 2. Right mouse click on the shortcut icon and select "Properties" then select the tab "Compatibility" and check the box "Run this program as an administrator" then click Apply and then OK. Now when you click the shortcut icon it will automatically ask for administrator rights. See also the screenshot below for the Compatibility tab.